European Journal of Chemistry

Synthesis of 5-arylazothiazoles, pyridines and thieno[2,3-b]pyridines derivatives containing 1,2,3-triazole moiety



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Abdou Osman Abdelhamid
Nadia Abdelhamid Abdel-Riheem
Tamer Tawhid El-Idreesy
Huda Refat Mahmoud Rashdan

Abstract

1-(2-(4,5-dihydro-3-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-5-phenylpyrazol-1-yl)-4-subs-tituted-thiazol-5-yl)-2-phenyldiazene (4) and substituted pyridines (5-12) were synthesized via reaction of 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-3-phenylprop-2-en-1-one with hydrazonoyl halides and active methylene compounds. Also, thieno[2,3-b]pyridines (14a-e) were prepared through reactions of 2-mercapto-6-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl)-4-phenyl-pyridine-3-carbonitrile with halo ester and halo ketones, respectively. The newly synthesized derivetived were elucidated by elemental analysis, spectral data and alternative synthetic routes wherever possobile.

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Abdelhamid, A. O.; Abdel-Riheem, N. A.; El-Idreesy, T. T.; Rashdan, H. R. M. Synthesis of 5-Arylazothiazoles, Pyridines and thieno[2,3-b]pyridines Derivatives Containing 1,2,3-Triazole Moiety. Eur. J. Chem. 2012, 3, 322-331.

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Cairo University, Giza, Egypt
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