European Journal of Chemistry 2012, 3(2), 129-137 | doi: https://doi.org/10.5155/eurjchem.3.2.129-137.579 | Get rights and content






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Convenient synthesis of some new pyrazolo[5,1-c]triazines, isoxazolo[3,4-d] pyrimidine and pyridine derivatives containing benzofuran moiety


Abdou Osman Abdelhamid (1,*) , Abdelgawad Ali Fahmi (2) , Amna Ali Mohamed Alsheflo (3)

(1) Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
(2) Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
(3) Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
(*) Corresponding Author

Received: 26 Dec 2011 | Revised: 04 Feb 2012 | Accepted: 04 Feb 2012 | Published: 30 Jun 2012 | Issue Date: June 2012

Abstract


Pyrazolo[5,1-c][1,2,4]triazine, [1,2,4]triazolo[3,4-c][1,2,4]triazine, benzo[4,5]-imidazo[2,1-c][1,2,4]triazine, isoxazole, isoxazolo[3,4-d]pyridazine, pyrazole, pyridine, substituted urea and phenyl carbamate derivatives containing benzofuran moiety were synthesized via reaction of sodium salt of 5-hydroxy-l-benzofuran-2-ylpropenone or 1-(benzofuran-2-yl)-3-(dimethylamino)prop-2-en-1-one with diazotized heterocyclic amines, hydroximoyl chlorides and active methylene compounds. The structures of all the newly synthesized compounds were confirmed by elemental analyses, spectral data, and alternative synthetic routes, whenever possible.

3_2_129_137_800


Keywords


Triazines; Pyridines; Pyrazoles; Isoxazoles; Hydrazones; Benzoimidazo[2,1-c][1,2,4]triazine

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DOI: 10.5155/eurjchem.3.2.129-137.579

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[1]. Elena V. Sadchikova, Daria L. Alexeeva, Valentine G. Nenajdenko
Trifluoroacetyl substituted pyrazolotriazines: synthesis and pathways of formation
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DOI: 10.1016/j.mencom.2020.03.016
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[2]. Ameen A. Abu-Hashem, Hoda A. R. Hussein, Ahmed S. Aly, Moustafa A. Gouda
Reactivity of Benzofuran Derivatives
Synthetic Communications  44(20), 2899, 2014
DOI: 10.1080/00397911.2014.907425
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[3]. Anhar Abdel-Aziem, Marwa Sayed El-Gendy, Abdou Osman Abdelhamid
Synthesis and antimicrobial activities of pyrido[2,3-d]pyrimidine, pyridotriazolopyrimidine, triazolopyrimidine, and pyrido[2,3-d:6,5d']dipyrimidine derivatives
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[4]. Assia Sid, Nouara Ziani, Ouafa Demmen-Debbih, Mahieddine Mokhtari, Kaddour Lamara
Synthesis, characterization and antimicrobial evaluation of 1-((5,3-diaryl)-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
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DOI: 10.5155/eurjchem.4.3.268-271.824
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[5]. Aisha Y. Hassan, Marwa T. Sarg, Ashraf H. Bayoumi, Moshira A. El-Deeb
Synthesis and Anticancer Evaluation of Some Novel 5-Amino[1,2,4]Triazole Derivatives
Journal of Heterocyclic Chemistry  55(6), 1450, 2018
DOI: 10.1002/jhet.3184
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[6]. I. V. Ledenyova, V. V. Didenko, Kh. S. Shikhaliev
Chemistry of Pyrazole-3(5)-Diazonium Salts (Review)*
Chemistry of Heterocyclic Compounds  50(9), 1214, 2014
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How to cite


Abdelhamid, A.; Fahmi, A.; Alsheflo, A. Eur. J. Chem. 2012, 3(2), 129-137. doi:10.5155/eurjchem.3.2.129-137.579
Abdelhamid, A.; Fahmi, A.; Alsheflo, A. Convenient synthesis of some new pyrazolo[5,1-c]triazines, isoxazolo[3,4-d] pyrimidine and pyridine derivatives containing benzofuran moiety. Eur. J. Chem. 2012, 3(2), 129-137. doi:10.5155/eurjchem.3.2.129-137.579
Abdelhamid, A., Fahmi, A., & Alsheflo, A. (2012). Convenient synthesis of some new pyrazolo[5,1-c]triazines, isoxazolo[3,4-d] pyrimidine and pyridine derivatives containing benzofuran moiety. European Journal of Chemistry, 3(2), 129-137. doi:10.5155/eurjchem.3.2.129-137.579
Abdelhamid, Abdou, Abdelgawad Ali Fahmi, & Amna Ali Mohamed Alsheflo. "Convenient synthesis of some new pyrazolo[5,1-c]triazines, isoxazolo[3,4-d] pyrimidine and pyridine derivatives containing benzofuran moiety." European Journal of Chemistry [Online], 3.2 (2012): 129-137. Web. 5 Aug. 2020
Abdelhamid, Abdou, Fahmi, Abdelgawad, AND Alsheflo, Amna. "Convenient synthesis of some new pyrazolo[5,1-c]triazines, isoxazolo[3,4-d] pyrimidine and pyridine derivatives containing benzofuran moiety" European Journal of Chemistry [Online], Volume 3 Number 2 (30 June 2012)

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DOI Link: https://doi.org/10.5155/eurjchem.3.2.129-137.579

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