European Journal of Chemistry 2011, 2(4), 509-513 | doi: https://doi.org/10.5155/eurjchem.2.4.509-513.463 | Get rights and content

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Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety


Mahmoud Abdallah Mohamed (1) , Eman Kamal Ahmad Abdelall (2) , Yasser Hassan Zaki (3) , Abdou Osman Abdelhamid (4,*)

(1) Department of Textile, Faculty of Industrial Education, Beni-Suef University, Beni-Suef-62514, Egypt
(2) Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef-62514, Egypt
(3) Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef-62514, Egypt
(4) Department of Chemistry, Faculty of Science, Cairo University, Giza-12613, Egypt
(*) Corresponding Author

Received: 18 May 2011 | Revised: 07 Jun 2011 | Accepted: 16 Jun 2011 | Published: 31 Dec 2011 | Issue Date: December 2011

Abstract


pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine and pyrimido[1,2-a] benzimidazole derivatives were synthesized by reaction of sodium salt of 3-hydroxy-(1-pyridin-2-yl)prop-2-en-1-one or sodium salt of 3-hydroxy-1-(pyridin-3-yl)prop-2-en-1-one with different heterocyclic amines in piperidenium acetate. Also, 3-amino-6-(2-pyridyl)thieno[2,3-b]pyridine derivatives were synthesized via reaction of pyridine-2-thione with various halogenated compounds. The structures of the newly synthesized compounds were confirmed by elemental analysis, spectral data, X-ray and alternative synthetic routes whenever possible.

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Keywords


Pyridines; Thieno[2,3-b]pyridine; Pyrazolo[1,5-a]pyrimidine; Triazolo[1,5-a]pyrimidine; Pyrimido[1,2-a]benzimidazole; Piperidenium acetate

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DOI: 10.5155/eurjchem.2.4.509-513.463

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Citations

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[1]. Sobhi Gomha, Sayed Ahmed, Abdou Abdelhamid
Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole Moiety
Molecules  20(1), 1357, 2015
DOI: 10.3390/molecules20011357
/


References


[1]. Highfield, J. A.; Mehta, L. K.; Parrick, J.; Wardman, P. Bioorg. Med. Chem. 2000, 8, 1065-1073.
http://dx.doi.org/10.1016/S0968-0896(00)00042-0

[2]. Wu, X. M.; Wu, X. S.; Xu, J. Y. J. Chin. Pharm. Univers. 1996, 27 (1), 641-646.

[3]. Klimesova, V.; Otcenasek, M.; Waissor, K. Eur. J. Med. Chem. 1996, 31, 389-395.
http://dx.doi.org/10.1016/0223-5234(96)89165-3

[4]. Son, J.; Zhao, L.; Basent, A.; Thapa, P.; Karki, R.; Na, Y.; Jahng, Y.; Jeong, T. C.; Jeong, B.; Lee, C.; Lee, E. Eur. J. Med. Chem. 2008, 43, 675-682.
http://dx.doi.org/10.1016/j.ejmech.2007.05.002
PMid:17673337

[5]. Bompart, J.; Giral, L.; Malicorne, G.; Puygrenier, M. Eur. J. Med. Chem. 1987, 22, 139-145.
http://dx.doi.org/10.1016/0223-5234(87)90009-2

[6]. Adachi, I.; Hiramatsu, Y. Jap. Pat., 03, 52, 890; Chem. Abstr. 1991, 115, 71573.

[7]. Furuya, S.; Takeyru, N.; Matsumoto, H. Jap. Pat., 09, 169, 766; Chem. Abstr. 1997, 127, 176416.

[8]. Furuya, S.; Choh, N.; Suzuki, N.; Imada, T. PCT Int. Appl. WO, 00, 00, 493; Chem. Abstr., 2000, 132, 64179s.

[9]. Bousquent, E.; Romero, G.; Guerrera, F.; Caruso, A.; Roxas, M. A. Farmaco Ed. Sci. 1985, 40, 869-875.

[10]. Leistner, S.; Wagener, G.; Guestscharo, M.; Glusa, E. Pharmazie 1986, 41, 54-55.
PMid:3960950

[11]. Wagner, G.; Leistner, S.; Vieweg, H.; Krasselt, U.; Prantz, J. Pharmazie 1993, 48, 514-518.
PMid:8415848

[12]. Youssefyeh, R. D.; Brown, R. E.; Wilson, J.; Shah, U.; Jones, H.; Loev, B.; Khandwala, A.; Leibowitz, M. J.; Sonnino-Goldman, P. J. Med. Chem. 1984, 27, 1639-1643.
http://dx.doi.org/10.1021/jm00378a019
PMid:6150114

[13]. Abdelhamid, A. O.; Ismail, Z. H.; Abdel-Gawad, S. M.; Ghorab, M. M.; Abdel-Aziem, A. Phosphorus Sulfur 2009, 184, 58-75.
http://dx.doi.org/10.1080/10426500802077630

[14]. Abdelhamid, A. O.; Mahmoud, M. A.; Zaki. Y. H. Phosphorus Sulfur 2008, 183, 1746-1754.
http://dx.doi.org/10.1080/10426500701734265

[15]. Ahmed, S. A.; Hussein, A. M.; Hozayen, W. H.; El-Gandour, A. H. H.; Abdelhamid, A. O. J. Heterocycl. Chem. 2007, 44, 803-810.
http://dx.doi.org/10.1002/jhet.5570440408

[16]. Abdelhamid, A. O.; Abdelaziz, H. M. J. Heterocyclic Chem. 2008, 45, 1719-1728.
http://dx.doi.org/10.1002/jhet.5570450625

[17]. Abdelhamid, A. O.; Abdelall, E. K. A; Abdel-Riheem, N. A.; dAhmed, S. A. Phosphorus Sulfur 2010, 185, 709-718.
http://dx.doi.org/10.1080/10426500902922933

[18]. Abdelhamid, A. O. J. Heterocycl. Chem. 2009, 46, 680-686.
http://dx.doi.org/10.1002/jhet.141

[19]. Ahmed, S. A.; Abdelhamid, A. O.; El-Ghandour, A. H.; Mohamed, A. M.; Mohamed, B. M. J. Chem. Res. 2008, 26-31.


Supporting information


The Supplementary Material for this article can be found online at: Supplementary files

How to cite


Mohamed, M.; Abdelall, E.; Zaki, Y.; Abdelhamid, A. Eur. J. Chem. 2011, 2(4), 509-513. doi:10.5155/eurjchem.2.4.509-513.463
Mohamed, M.; Abdelall, E.; Zaki, Y.; Abdelhamid, A. Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety. Eur. J. Chem. 2011, 2(4), 509-513. doi:10.5155/eurjchem.2.4.509-513.463
Mohamed, M., Abdelall, E., Zaki, Y., & Abdelhamid, A. (2011). Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety. European Journal of Chemistry, 2(4), 509-513. doi:10.5155/eurjchem.2.4.509-513.463
Mohamed, Mahmoud, Eman Kamal Ahmad Abdelall, Yasser Hassan Zaki, & Abdou Osman Abdelhamid. "Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety." European Journal of Chemistry [Online], 2.4 (2011): 509-513. Web. 19 Oct. 2021
Mohamed, Mahmoud, Abdelall, Eman, Zaki, Yasser, AND Abdelhamid, Abdou. "Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety" European Journal of Chemistry [Online], Volume 2 Number 4 (31 December 2011)

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