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Development of spectrofluorimetric stability indicating method for determination of naratriptan hydrochloride in pharmaceutical dosage form
Mohamed Rizk (1) , Maha Sultan (2) , Mona Elshahed (3) , Mourad Ali (4,*)
(1) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, EinHelwan, 11795, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, EinHelwan, 11795, Cairo, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, EinHelwan, 11795, Cairo, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, EinHelwan, 11795, Cairo, Egypt
(*) Corresponding Author
Received: 06 May 2018 | Revised: 29 Jun 2018 | Accepted: 29 Jun 2018 | Published: 30 Sep 2018 | Issue Date: September 2018
A stability indicating spectrofluorimetric method is developed for the determination of naratriptan hydrochloride in pharmaceutical formulation. The proposed method is based on investigation of the native fluorescence spectral behaviour of the drug in aqueous phosphate buffer (pH = 7.0±0.2).The fluorescence intensity is measured at 355.0 nm after excitation at 230.0 nm. The fluorescence-concentration plot is linear over the concentration range 8.0-80.0 ng/mL, with lower detection limit of 2.6 ng/mL and quantification limit of 7.6 ng/mL. The method is successfully applied to the analysis of the studied drug in its commercial tablet. Furthermore, the proposed method is applied in dissolution study of tablet; the results are in good agreement with those obtained with the reference method. The proposed method is approved to be a stability-indicating assay after exposure of the drug to different forced degradation conditions, such as acidic, alkaline and oxidative conditions, according to International Conference on Harmonization guidelines.
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. Moffat, A. C.; Osselton, M. D.; Widdop, B.; Watts, J. Clarke's analysis of drugs and poisons in pharmaceutical, body fluids and postmortem material, 4th Edition, Pharmaceutical Press, London, 2011.
. The United States Pharmacopeia and National Formulary (USP 29-NF 24), 2006 Edition, pp. 1487-1488, 2006.
. Sweetman, S., Martindale: The Complete Drug Reference, 36th edition, Pharmaceutical Press, London, 2009.
. Velasco-Aguirre, C.; Alvarez-Lueje, A. Talanta 2010, 82, 796-802.
. Shelke, S.; Shahi, S.; Patil, V.; Kale, S. Asian J. Biomed. Pharm. Sci. 2015, 5, 36-39.
. Swamy. G, K.; Kumar, J. M. R.; Rao, J. V. L. N. S.; Kumar, U. A. Indo Am. J. Pharm. Sci. 2011, 1, 253-256.
. Borse, J. S.; Shirkhedkar, A. A. J. Appl. Pharm. Sci. 2012, 6, 227-229.
. Reddy, R. B. D.; Charitha, A.; Sowjanya, G. N.; Kumar, G. S.; Gananadhamu, S.; Kishore, G. K.; Chaitanya, K. K. J. Glob. Trends Phar. Sci. 2013, 4, 1107-1110.
. Prajapati, P. B.; Chotalia, J.; Bodiwala, K. B.; Marolia, B. P.; Shah, S. A. J. Chromatogr. Sci. 2016, 54, 1129-1136.
. Ramu, G.; Babu, A. B.; Kumar, M. S.; Rambabu, C. Braz. J. Pharm. Res. 2012, 5, 2627-2630.
. Dulery, B. D.; Petty, M. A.; Schoun, J.; David, M.; Huebert, N. D. J. Pharmaceut. Biomed. 1997, 15, 1009-1020.
. Vishwanathan, K.; Bartlett, M. G.; Stewart, J. T. Rapid Commun. Mass Spectrom. 2000, 1, 168-172.
. Yadav, M.; Patel, C.; Patel, M.; Mishra, T.; Singhal, P.; Shrivastav, P. S.; Baxi, G. A. J. Chromatogr. Sci. 2011, 49, 101-107.
. Challa, B. R.; Awen, B. Z. S.; Chandu, B. R.; Shaik, R. P. Braz. J. Pharm. Sci. 2011, 47, 13-22.
. Wehry, E. L.; Settle, A. F. Handbook of Instrumental Techniques for Analytical Chemistry. Chapter 26, Molecular Fluorescence and Phosphorescence Spectrometry, Prentice Hall, New Jersey, USA, 1997.
. Walash, M. I.; Belal, F.; El-Enany, N.; Eid, M.; El-Shaheny, R. N. J. Fluoresc. 2011, 21, 1659-1667.
. Walash, M. I.; Belal, F.; El-Enany, N.; Eid, M.; El-Shaheny, R. N. Luminescence 2011, 26, 670-679.
. JASCO, Model FP-6200 Spectrofluorometer Instruction Manual, Ishikawa-Cho, Hachioji, Tokyo, Japan, 2000.
. ICH Harmonized Tripartite Guideline Q2 (R1). Validation of analytical procedures: text and methodology, International Conference on Harmonization. Geneva, Switzerland; 2005.
. Miller, J. N.; Miller, J. C. Statistics and chemometrics for analytical chemistry, 5th Edition, Pearson Education: England, 2005.
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DOI Link: https://doi.org/10.5155/eurjchem.9.3.251-257.1731
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European Journal of Chemistry 2018, 9(3), 251-257 | doi: https://doi.org/10.5155/eurjchem.9.3.251-257.1731 | Get rights and content
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