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Kinetic fluorimetric determination of Mesna (Sodium-2-mercaptoethane sulfonate) in drug products through oxidation with cerium(IV)
Mohamed Rizk (1)
, Elham Anwer Taha (2) , Shereen Mowaka (3,*) , Youmna Mosaad Abdallah (4) (1) Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
(2) National Organization for Drug Control and Research, El Agoza, Giza, 12311, Egypt
(3) Department of Analytical Chemistry, Faculty of Pharmacy, British University in Egypt, Cairo, 11837, Egypt
(4) National Organization for Drug Control and Research, El Agoza, Giza, 12311, Egypt
(*) Corresponding Author
Received: 01 Apr 2013 | Revised: 26 Apr 2013 | Accepted: 01 May 2013 | Published: 30 Sep 2013 | Issue Date: September 2013
Abstract
A simple and sensitive kinetic spectrofluorimetric method was developed for the determination of mesna in drug products. The method is based on oxidation of the studied drug with cerium(IV) ammonium sulphate in acidic medium. The fluorescence of the produced Ce(III) was measured at 359 nm after excitation at 259 nm. The method involves determination of mesna by kinetic study of its oxidation at 100 oC for a fixed time of 20 min. The different experimental parameters affecting development and stability of reaction product were carefully studied and optimized. The fluorescence-concentration plot was rectilinear over the concentration range of 0.50-4.00 ng/mL, with a minimum detectability of 0.17 ng/mL. The method was successfully applied for the determination of mesna in its drug product. The results obtained were found to be in good agreement with those obtained with an official method of the investigated drug. The validity of the method was assessed according to USP guidelines.
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DOI: 10.5155/eurjchem.4.3.220-225.785
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Citations
[1]. Rim S. Haggag, Dina A. Gawad, Saeid F. Belal, Hadil M. Elbardisy
Spectrophotometric determination of the sulfhydryl containing drug mesna
Bulletin of Faculty of Pharmacy, Cairo University 54(1), 21, 2016
DOI: 10.1016/j.bfopcu.2015.12.002
[2]. Rim S. Haggag, Dina A. Gawad, Saeid F. Belal, Hadil M. Elbardisy
Spectrophotometric and spectrofluorimetric determination of mesna, acetylcysteine and timonacic acid through the reaction with acetoxymercuri fluorescein
Analytical Methods 8(11), 2479, 2016
DOI: 10.1039/C5AY02279G
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DOI Link: https://doi.org/10.5155/eurjchem.4.3.220-225.785
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European Journal of Chemistry 2013, 4(3), 220-225 | doi: https://doi.org/10.5155/eurjchem.4.3.220-225.785 | Get rights and content
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