European Journal of Chemistry 2013, 4(3), 220-225. doi:10.5155/eurjchem.4.3.220-225.785

Kinetic fluorimetric determination of Mesna (Sodium-2-mercaptoethane sulfonate) in drug products through oxidation with cerium(IV)


Mohamed Rizk (1) , Elham Anwer Taha (2) , Shereen Mowaka (3,*) , Youmna Mosaad Abdallah (4)

(1) Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
(2) National Organization for Drug Control and Research, El Agoza, Giza, 12311, Egypt
(3) Department of Analytical Chemistry, Faculty of Pharmacy, British University in Egypt, Cairo, 11837, Egypt
(4) National Organization for Drug Control and Research, El Agoza, Giza, 12311, Egypt
(*) Corresponding Author

Received: 01 Apr 2013, Accepted: 01 May 2013, Published: 30 Sep 2013

Abstract


A simple and sensitive kinetic spectrofluorimetric method was developed for the determination of mesna in drug products. The method is based on oxidation of the studied drug with cerium(IV) ammonium sulphate in acidic medium. The fluorescence of the produced Ce(III) was measured at 359 nm after excitation at 259 nm. The method involves determination of mesna by kinetic study of its oxidation at 100 oC for a fixed time of 20 min. The different experimental parameters affecting development and stability of reaction product were carefully studied and optimized. The fluorescence-concentration plot was rectilinear over the concentration range of 0.50-4.00 ng/mL, with a minimum detectability of 0.17 ng/mL. The method was successfully applied for the determination of mesna in its drug product. The results obtained were found to be in good agreement with those obtained with an official method of the investigated drug. The validity of the method was assessed according to USP guidelines.

4_3_220_225

Keywords


Mesna; Uromes; Oxidation; Cerium(IV); Quantum yield; Kinetic fluorimetric determination

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.4.3.220-225.785

Article Metrics


This Abstract was viewed 897 times | PDF Article downloaded 1535 times

Citations

/


[1]. Rim S. Haggag, Dina A. Gawad, Saeid F. Belal, Hadil M. Elbardisy
Spectrophotometric determination of the sulfhydryl containing drug mesna
Bulletin of Faculty of Pharmacy, Cairo University  54(1), 21, 2016
DOI: 10.1016/j.bfopcu.2015.12.002
/


[2]. Rim S. Haggag, Dina A. Gawad, Saeid F. Belal, Hadil M. Elbardisy
Spectrophotometric and spectrofluorimetric determination of mesna, acetylcysteine and timonacic acid through the reaction with acetoxymercuri fluorescein
Analytical Methods  8(11), 2479, 2016
DOI: 10.1039/C5AY02279G
/


References

[1]. Reynolds, J. E. F. Martindale The Extra Pharmacopoeia, 29th edition, Pharmaceutical Press, London, 1989.

[2]. Glowackia, R.; Wojcika, K.; Bald, E. J Chromatogr. A 2001, 914, 29-35.
http://dx.doi.org/10.1016/S0021-9673(00)01064-5

[3]. Verschraagen, M.; Bosma, M.; Ursula, Z. T.; Torun, E.; Van Dervijgh, W. J. F. J. Chromatogr. B 2003, 783, 33-42.
http://dx.doi.org/10.1016/S1570-0232(02)00470-1

[4]. El-Yazigi, A.; Ahmed, Y.; Sameer, A. R. Ther. Drug Monit. 1995, 17, 153-158.
http://dx.doi.org/10.1097/00007691-199504000-00009
PMid:7624904

[5]. Mare, S.; Penugonda, S.; Ercal, N. Biomed. Chromatogr. 2005, 19, 80–86.
http://dx.doi.org/10.1002/bmc.420
PMid:15372507

[6]. Skowron, M.; Ciesielski, W. Chem. Anal. -Warsaw 2009, 54, 743-751.

[7]. Ahmed, N. R. Iraqi Nat. J. Chem. 2011, 44, 492-500.

[8]. Rizk, M.; Taha, E. A.; Mowaka, S.; Abdallah, Y. M. Chem. Sci. Rev. Lett. 2012, 1, 140-147.

[9]. El-Didamony, A. M. J. Chin. Chem. Soc. 2009, 56, 755-762.

[10]. Taha, E. A.; Hasan, N. Y.; Abdel Aal, F.; Abdel Fattah, L. E. B. Fac. Pharm. Cairo Univ. 2005, 43, 9-22.

[11]. Darwish, I. A.; Khedra, A. S.; Askala, H. F.; Mahmoud, R. M. Farmaco 2005, 60, 555-562.
http://dx.doi.org/10.1016/j.farmac.2005.04.003
PMid:15932755

[12]. Mohamed, F. A.; Mohamed, H. A.; Hussein, S. A.; Ahmed, S. A. J. Pharmceut. Biomed. Anal. 2005, 39, 139-146.
http://dx.doi.org/10.1016/j.jpba.2005.03.024
PMid:16085135

[13]. Mahgoub, H. J. Pharmceut. Biomed. Anal. 2003, 31, 767-774.
http://dx.doi.org/10.1016/S0731-7085(02)00657-X

[14]. Alarafaj, N. A. A. J. Pharmaceut. Biomed. Anal. 2002, 28, 331-335.
http://dx.doi.org/10.1016/S0731-7085(01)00619-7

[15]. Walash, M. I.; Belal, F.; El Enany, N.; Abdelal, A. A. Int. J. Biomed. Sci. 2009, 5, 146-157.
PMid:23675129 PMCid:PMC3614771

[16]. The United States Pharmacopeia, USP 34, National Formulary, The United States Pharmacopeial Convention, Inc., Rockville, 3433-3434.

[17]. Trost, B. M.; Ley, S. V.; Fleming, I. Comprehensive Organic Synthesis, 1st ed., Pergamon Press, London, 1991.
PMCid:PMC1077619

[18]. Tabrizi, A. B. B. Kor. Chem. Soc. 2006, 27, 1199-1202.
http://dx.doi.org/10.5012/bkcs.2006.27.8.1199

[19]. Ramadan, N. K. J. Appl. Pharm. Sci. 2012, 2, 112-119.

[20]. El-Didamony, A. M. J. Chil. Chem. Soc. 2012, 57, 1404-1408.
http://dx.doi.org/10.4067/S0717-97072012000400015

[21]. Suganthi, A. Int. J. Pharm. Chem. Sci. 2013, 2, 938-941.

[22]. Jeffery, G. H.; Bassett, J.; Mendham, J.; Dennery, R. C. Vogel's Textbook of Quantitative Chemical Analysis, 5th ed., Bath Press: England, 1989.

[23]. Yatsimirskii, K. B. Kinetic Methods of Analysis, Pergamon Press, London, 1966.

[24]. Martin, A. Physical Pharmacy, 3rd ed., Lea & Febiger, USA, 1983.

[25]. The United States Pharmacopeia, USP 34, The National Formulary, The United States Pharmacopeial Convention, Inc., Rockville, 779-782.

[26]. Manufacturer (EMIC) Method of analysis of mesna in Uromes ampoule by personal communication.

[27]. Calcut, R.; Boddy, R. Statistics for Analytical Chemists, Chapmann & Hall, London, 1983.

[28]. Rose, J. Advanced Physicochemical Experiments, Pitman, London, 1964.

[29]. Tang, B.; Wang, X.; Jia, B.; Niu, J.; Ying, Y. W.; Chen, Z.; Wang, Y. Anal. Lett. 2003, 36, 2985-2997.
http://dx.doi.org/10.1081/AL-120026416


How to cite


Rizk, M.; Taha, E.; Mowaka, S.; Abdallah, Y. Eur. J. Chem. 2013, 4(3), 220-225. doi:10.5155/eurjchem.4.3.220-225.785
Rizk, M.; Taha, E.; Mowaka, S.; Abdallah, Y. Kinetic fluorimetric determination of Mesna (Sodium-2-mercaptoethane sulfonate) in drug products through oxidation with cerium(IV). Eur. J. Chem. 2013, 4(3), 220-225. doi:10.5155/eurjchem.4.3.220-225.785
Rizk, M., Taha, E., Mowaka, S., & Abdallah, Y. (2013). Kinetic fluorimetric determination of Mesna (Sodium-2-mercaptoethane sulfonate) in drug products through oxidation with cerium(IV). European Journal of Chemistry, 4(3), 220-225. doi:10.5155/eurjchem.4.3.220-225.785
Rizk, Mohamed, Elham Anwer Taha, Shereen Mowaka, & Youmna Mosaad Abdallah. "Kinetic fluorimetric determination of Mesna (Sodium-2-mercaptoethane sulfonate) in drug products through oxidation with cerium(IV)." European Journal of Chemistry [Online], 4.3 (2013): 220-225. Web. 17 Sep. 2019
Rizk, Mohamed, Taha, Elham, Mowaka, Shereen, AND Abdallah, Youmna. "Kinetic fluorimetric determination of Mesna (Sodium-2-mercaptoethane sulfonate) in drug products through oxidation with cerium(IV)" European Journal of Chemistry [Online], Volume 4 Number 3 (30 September 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.3.220-225.785

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2019  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.