European Journal of Chemistry

Kinetic fluorimetric determination of Mesna (Sodium-2-mercaptoethane sulfonate) in drug products through oxidation with cerium(IV)

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Published: Sep 30, 2013
DOI: https://doi.org/10.5155/eurjchem.4.3.220-225.785
Keywords:
Mesna, Uromes, Oxidation, Cerium(IV), Quantum yield, Kinetic fluorimetric determination
Section
Research Article
Issue
Vol. 4 No. 3 (2013): September 2013
Dates
Received 2013-04-01
Accepted 2013-05-01
Published 2013-09-30


Main Article Content

Mohamed Rizk
Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
Elham Anwer Taha
National Organization for Drug Control and Research, El Agoza, Giza, 12311, Egypt
Shereen Mowaka
Department of Analytical Chemistry, Faculty of Pharmacy, British University in Egypt, Cairo, 11837, Egypt
Youmna Mosaad Abdallah
National Organization for Drug Control and Research, El Agoza, Giza, 12311, Egypt

Abstract

A simple and sensitive kinetic spectrofluorimetric method was developed for the determination of mesna in drug products. The method is based on oxidation of the studied drug with cerium(IV) ammonium sulphate in acidic medium. The fluorescence of the produced Ce(III) was measured at 359 nm after excitation at 259 nm. The method involves determination of mesna by kinetic study of its oxidation at 100 oC for a fixed time of 20 min. The different experimental parameters affecting development and stability of reaction product were carefully studied and optimized. The fluorescence-concentration plot was rectilinear over the concentration range of 0.50-4.00 ng/mL, with a minimum detectability of 0.17 ng/mL. The method was successfully applied for the determination of mesna in its drug product. The results obtained were found to be in good agreement with those obtained with an official method of the investigated drug. The validity of the method was assessed according to USP guidelines.

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How to Cite
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Rizk, M.; Taha, E. A.; Mowaka, S.; Abdallah, Y. M. Kinetic Fluorimetric Determination of Mesna (Sodium-2-Mercaptoethane Sulfonate) in Drug Products through Oxidation With cerium(IV). Eur. J. Chem. 2013, 4, 220-225.

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References

[1]. Reynolds, J. E. F. Martindale The Extra Pharmacopoeia, 29th edition, Pharmaceutical Press, London, 1989.

[2]. Glowackia, R.; Wojcika, K.; Bald, E. J Chromatogr. A 2001, 914, 29-35.
http://dx.doi.org/10.1016/S0021-9673(00)01064-5

[3]. Verschraagen, M.; Bosma, M.; Ursula, Z. T.; Torun, E.; Van Dervijgh, W. J. F. J. Chromatogr. B 2003, 783, 33-42.
http://dx.doi.org/10.1016/S1570-0232(02)00470-1

[4]. El-Yazigi, A.; Ahmed, Y.; Sameer, A. R. Ther. Drug Monit. 1995, 17, 153-158.
http://dx.doi.org/10.1097/00007691-199504000-00009
PMid:7624904

[5]. Mare, S.; Penugonda, S.; Ercal, N. Biomed. Chromatogr. 2005, 19, 80–86.
http://dx.doi.org/10.1002/bmc.420
PMid:15372507

[6]. Skowron, M.; Ciesielski, W. Chem. Anal. -Warsaw 2009, 54, 743-751.

[7]. Ahmed, N. R. Iraqi Nat. J. Chem. 2011, 44, 492-500.

[8]. Rizk, M.; Taha, E. A.; Mowaka, S.; Abdallah, Y. M. Chem. Sci. Rev. Lett. 2012, 1, 140-147.

[9]. El-Didamony, A. M. J. Chin. Chem. Soc. 2009, 56, 755-762.

[10]. Taha, E. A.; Hasan, N. Y.; Abdel Aal, F.; Abdel Fattah, L. E. B. Fac. Pharm. Cairo Univ. 2005, 43, 9-22.

[11]. Darwish, I. A.; Khedra, A. S.; Askala, H. F.; Mahmoud, R. M. Farmaco 2005, 60, 555-562.
http://dx.doi.org/10.1016/j.farmac.2005.04.003
PMid:15932755

[12]. Mohamed, F. A.; Mohamed, H. A.; Hussein, S. A.; Ahmed, S. A. J. Pharmceut. Biomed. Anal. 2005, 39, 139-146.
http://dx.doi.org/10.1016/j.jpba.2005.03.024
PMid:16085135

[13]. Mahgoub, H. J. Pharmceut. Biomed. Anal. 2003, 31, 767-774.
http://dx.doi.org/10.1016/S0731-7085(02)00657-X

[14]. Alarafaj, N. A. A. J. Pharmaceut. Biomed. Anal. 2002, 28, 331-335.
http://dx.doi.org/10.1016/S0731-7085(01)00619-7

[15]. Walash, M. I.; Belal, F.; El Enany, N.; Abdelal, A. A. Int. J. Biomed. Sci. 2009, 5, 146-157.
PMid:23675129 PMCid:PMC3614771

[16]. The United States Pharmacopeia, USP 34, National Formulary, The United States Pharmacopeial Convention, Inc., Rockville, 3433-3434.

[17]. Trost, B. M.; Ley, S. V.; Fleming, I. Comprehensive Organic Synthesis, 1st ed., Pergamon Press, London, 1991.
PMCid:PMC1077619

[18]. Tabrizi, A. B. B. Kor. Chem. Soc. 2006, 27, 1199-1202.
http://dx.doi.org/10.5012/bkcs.2006.27.8.1199

[19]. Ramadan, N. K. J. Appl. Pharm. Sci. 2012, 2, 112-119.

[20]. El-Didamony, A. M. J. Chil. Chem. Soc. 2012, 57, 1404-1408.
http://dx.doi.org/10.4067/S0717-97072012000400015

[21]. Suganthi, A. Int. J. Pharm. Chem. Sci. 2013, 2, 938-941.

[22]. Jeffery, G. H.; Bassett, J.; Mendham, J.; Dennery, R. C. Vogel's Textbook of Quantitative Chemical Analysis, 5th ed., Bath Press: England, 1989.

[23]. Yatsimirskii, K. B. Kinetic Methods of Analysis, Pergamon Press, London, 1966.

[24]. Martin, A. Physical Pharmacy, 3rd ed., Lea & Febiger, USA, 1983.

[25]. The United States Pharmacopeia, USP 34, The National Formulary, The United States Pharmacopeial Convention, Inc., Rockville, 779-782.

[26]. Manufacturer (EMIC) Method of analysis of mesna in Uromes ampoule by personal communication.

[27]. Calcut, R.; Boddy, R. Statistics for Analytical Chemists, Chapmann & Hall, London, 1983.

[28]. Rose, J. Advanced Physicochemical Experiments, Pitman, London, 1964.

[29]. Tang, B.; Wang, X.; Jia, B.; Niu, J.; Ying, Y. W.; Chen, Z.; Wang, Y. Anal. Lett. 2003, 36, 2985-2997.
http://dx.doi.org/10.1081/AL-120026416

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