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Micellar high performance liquid chromatographic determination of tinidazole in combination with ciprofloxacin or norfloxacin in bulk, pharmaceutical dosage forms and in spiked human plasma
Mohamed Rizk (1)
, Safaa Shafik Toubar (2) , Maha Mahmoud Abou El‐Alamin (3,*) , Marwa Mohamed Mahmoud Azab (4) (1) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(*) Corresponding Author
Received: 26 Feb 2014 | Accepted: 27 Mar 2014 | Published: 30 Sep 2014 | Issue Date: September 2014
Abstract
A micellar liquid chromatographic method was developed for determination of tinidazole in bulk, dosage forms and human plasma using intersil cyano column and a mobile phase of 0.1 M sodium dodecyl sulphate, 20% 1-propanol, 0.3% triethylamine in 0.02 M orthophosphoric acid:water (60:40, v:v) (pH = 4). The U.V. detection was achieved at 311 nm. Various chromatographic parameters were investigated to select the optimum conditions for the separation, e.g. types of columns, pH of mobile phase, concentration of sodium dodecyl sulphate, 1-propanol, triethylamine, etc. The method was linear over the concentration range 40-200 µg/mL with regression coefficient 0.999. The result obtained by the proposed method was compared with that obtained by the reference HPLC technique. Furthermore, the proposed method was successfully applied as stability-indicating method for determination of tinidazole under different stressed conditions. The method showed good selectivity, repeatability, linearity and sensitivity according to the evaluation of the validation parameters.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.5.3.439-445.1037
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Egyptian Research and Development Company, Egypt
Citations
[1]. Sai Sandeep Mannemala, Valliappan Kannappan
Multiple response optimization of a liquid chromatographic method for determination of fluoroquinolone and nitroimidazole antimicrobials in serum and urine
Clinical Biochemistry 49(7-8), 587, 2016
DOI: 10.1016/j.clinbiochem.2015.12.013
[2]. Noura Hemdan Abou‐Taleb, Dalia Rashad El‐Wasseef, Dina Tawfik El‐Sherbiny, Saadia Mohamed El‐Ashry
Multiobjective optimization strategy based on desirability functions used for the microemulsion liquid chromatographic separation and quantification of norfloxacin and tinidazole in plasma and formulations
Journal of Separation Science 38(6), 901, 2015
DOI: 10.1002/jssc.201401203
[3]. Roshdy E. Saraya, Yasser F. Hassan, Walid E. Eltoukhi, Baher I. Salman
Application of the green analytical procedure index to the simultaneous analysis of co-formulated tinidazole and ciprofloxacin in pure form, tablet dosage form, and human plasma using an environmentally friendly micellar high-performance thin-layer chromatographic technology
JPC – Journal of Planar Chromatography – Modern TLC 36(1), 21, 2023
DOI: 10.1007/s00764-023-00225-4
[4]. Maha Osama El-Kayal, Maha Nasr Sayed, Nahed Dawood Mortada, Seham Elkheshen
Development and validation of a simple and rapid UPLC method for the in-vitro estimation of (-)-epigallocatechin-3-gallate in lipid-based formulations
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[5]. Amira H. Kamal, Samah F. El-Malla
Mixed micellar liquid chromatographic method for simultaneous determination of norfloxacin and tinidazole in pharmaceutical tablets
Microchemical Journal 150, 104151, 2019
DOI: 10.1016/j.microc.2019.104151
[6]. Eman A. Bahgat, Manal S. Elmasry, Rania A. Sayed
The application of experimental design and green analytical chemistry in HPLC strategy for the determination of five drugs used in antimicrobial combination therapy
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DOI: 10.1016/j.microc.2023.108915
[7]. Amira H. Kamal, Samah F. El-Malla
Factor Space Analysis and Dual Wavelength Spectrophotometric Methods for Simultaneous Determination of Norfloxacin and Tinidazole in Tablet
Analytical Chemistry Letters 8(3), 393, 2018
DOI: 10.1080/22297928.2018.1470941
[8]. roshdy saraya, Yasser F. Hassan, Walid E. Eltoukhi, Baher I. Salman
Application of the Gapi Index to the Simultaneous Analysis of Co-Formulated Tinidazole and Ciprofloxacin in Pure Form and Tablet Dosage Form Using an Environmentally Friendly Micellar Hptlc Technology
SSRN Electronic Journal , , 2022
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DOI Link: https://doi.org/10.5155/eurjchem.5.3.439-445.1037
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European Journal of Chemistry 2014, 5(3), 439-445 | doi: https://doi.org/10.5155/eurjchem.5.3.439-445.1037 | Get rights and content
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