1,2,4-Triazine Chemistry Part I: Orientation of cyclization reactions of functionalized 1,2,4-triazine derivatives

Reda Mohammady Abdel-Rahman, Mohammed Saleh Tawfik Makki, Tarik El-Sayed Ali, Magdy Ahmed Ibrahim


Orientation of heterocyclization reactions of functionalized 1,2,4-triazines were studied by effect of substituents in 1,2,4-triazine moieties, type of the solvent used in the reaction and the temperature effect. Also, it was found that cyclization process depended mainly on the chemoselective and regioselectivity states of the parent substrate as well as preferring cite of ring closure.



1,2,4-Triazines; Chemical reactivity; Cyclization reactions

European Journal of Chemistry, 1 (3), (2010), 236-245

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DOI: http://dx.doi.org/10.5155/eurjchem.1.3.236-245.54