European Journal of Chemistry 2014, 5(3), 439-445 | doi: https://doi.org/10.5155/eurjchem.5.3.439-445.1037 | Get rights and content






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Micellar high performance liquid chromatographic determination of tinidazole in combination with ciprofloxacin or norfloxacin in bulk, pharmaceutical dosage forms and in spiked human plasma


Mohamed Rizk (1) , Safaa Shafik Toubar (2) , Maha Mahmoud Abou El‐Alamin (3,*) , Marwa Mohamed Mahmoud Azab (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(*) Corresponding Author

Received: 26 Feb 2014 | Accepted: 27 Mar 2014 | Published: 30 Sep 2014 | Issue Date: September 2014

Abstract


A micellar liquid chromatographic method was developed for determination of tinidazole in bulk, dosage forms and human plasma using intersil cyano column and a mobile phase of 0.1 M sodium dodecyl sulphate, 20% 1-propanol, 0.3% triethylamine in 0.02 M orthophosphoric acid:water (60:40, v:v) (pH = 4). The U.V. detection was achieved at 311 nm. Various chromatographic parameters were investigated to select the optimum conditions for the separation, e.g. types of columns, pH of mobile phase, concentration of sodium dodecyl sulphate, 1-propanol, triethylamine, etc. The method was linear over the concentration range 40-200 µg/mL with regression coefficient 0.999. The result obtained by the proposed method was compared with that obtained by the reference HPLC technique. Furthermore, the proposed method was successfully applied as stability-indicating method for determination of tinidazole under different stressed conditions. The method showed good selectivity, repeatability, linearity and sensitivity according to the evaluation of the validation parameters.


Keywords


Stability; Tinidazole; Method validation; Anti-protozoal drugs; Micellar liquid chromatography; Optimization and system suitability

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DOI: 10.5155/eurjchem.5.3.439-445.1037

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Funding information


Egyptian Research and Development Company, Egypt

Citations

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[2]. Noura Hemdan Abou-Taleb, Dalia Rashad El-Wasseef, Dina Tawfik El-Sherbiny, Saadia Mohamed El-Ashry
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[4]. Amira H. Kamal, Samah F. El-Malla
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[5]. Amira H. Kamal, Samah F. El-Malla
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[6]. Rania N. El-Shaheny, Mahmoud H. El-Maghrabey, Fathalla F. Belal
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How to cite


Rizk, M.; Toubar, S.; El‐Alamin, M.; Azab, M. Eur. J. Chem. 2014, 5(3), 439-445. doi:10.5155/eurjchem.5.3.439-445.1037
Rizk, M.; Toubar, S.; El‐Alamin, M.; Azab, M. Micellar high performance liquid chromatographic determination of tinidazole in combination with ciprofloxacin or norfloxacin in bulk, pharmaceutical dosage forms and in spiked human plasma. Eur. J. Chem. 2014, 5(3), 439-445. doi:10.5155/eurjchem.5.3.439-445.1037
Rizk, M., Toubar, S., El‐Alamin, M., & Azab, M. (2014). Micellar high performance liquid chromatographic determination of tinidazole in combination with ciprofloxacin or norfloxacin in bulk, pharmaceutical dosage forms and in spiked human plasma. European Journal of Chemistry, 5(3), 439-445. doi:10.5155/eurjchem.5.3.439-445.1037
Rizk, Mohamed, Safaa Shafik Toubar, Maha Mahmoud Abou El‐Alamin, & Marwa Mohamed Mahmoud Azab. "Micellar high performance liquid chromatographic determination of tinidazole in combination with ciprofloxacin or norfloxacin in bulk, pharmaceutical dosage forms and in spiked human plasma." European Journal of Chemistry [Online], 5.3 (2014): 439-445. Web. 27 May. 2020
Rizk, Mohamed, Toubar, Safaa, El‐Alamin, Maha, AND Azab, Marwa. "Micellar high performance liquid chromatographic determination of tinidazole in combination with ciprofloxacin or norfloxacin in bulk, pharmaceutical dosage forms and in spiked human plasma" European Journal of Chemistry [Online], Volume 5 Number 3 (30 September 2014)

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DOI Link: https://doi.org/10.5155/eurjchem.5.3.439-445.1037

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